Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: An observational prospective analysis

In a multiethnic cohort of 162 obese youth with baseline impaired glucose tolerance followed prospectively for a mean of 2.9 years with standard-of-care dietary counseling, 65% reverted to normal gluc

Effect: improvement; 65% reversion rate (IGT to NGT)

Non-Hispanic White ethnic background conferred a 5-fold greater odds of reverting from impaired glucose tolerance to normal glucose tolerance compared to Non-Hispanic Black, after adjusting for family

Effect: improvement; OR 5.06; CI: 95% CI 1.86, 13.76

Obese youth who reverted from IGT to NGT exhibited a 4-fold increase in oral disposition index, reflecting dynamic beta-cell hyper-responsiveness, while those who persisted with IGT or progressed to T

Effect: improvement; 4-fold increase in oDI (from 0.94 to 3.90)

Ethnicity was not a statistically significant predictor of progression from normal glucose tolerance to impaired glucose tolerance in obese youth, unlike its strong role in predicting IGT reversion, w

Effect: null; OR not reported (p=NS)

Among 364 obese youth with normal glucose tolerance at baseline, 14% progressed to impaired glucose tolerance over 2.9 years, with progression characterized by a significant decline in beta-cell funct

Effect: decline; 14% progression rate (NGT to IGT)