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Finding
Finding
improvement
Obese youth who reverted from IGT to NGT exhibited a 4-fold increase in oral disposition index, reflecting dynamic beta-cell hyper-responsiveness, while those who persisted with IGT or progressed to T2D showed declining insulin secretion, with the hyper-secretive state persisting even after reversion to normal glucose tolerance.
| Effect size | 4-fold increase in oDI (from 0.94 to 3.90) |
| Comparator | Youth with persistent IGT (oDI decreased from 1.73 to 1.31, p=0.020) and youth who progressed to T2D (oDI decreased from 1.66 to 0.20, p=0.002) |
| Effect summary | improvement; 4-fold increase in oDI (from 0.94 to 3.90) |
| Effect modifiers | [{"modifier": "Ethnicity (NHW vs NHB)", "interaction_p": "p=0.045", "direction": "amplifies", "stratum_details": "NHW with IGT at baseline exhibited 189% median yearly oDI increase vs 83% in NHB (p=0.011). Follow-up oDI in NHW was 2.32 points higher than NHB after adjustment (95% CI 0.30-4.60, p=0.045).", "plain_language": "White youth showed a much stronger beta-cell recovery response than Black youth, with roughly twice the yearly improvement in insulin secretion capacity", "annotation_notes": "Ethnicity was the sole significant and independent predictor of oDI at follow-up among those with baseline IGT. This modifier IS the central finding of the paper."}] |
Connected entities
Interventions
Conditions
Populations
Source
PMC6190831
Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: An observational prospective analysis