Insulin Resistance Predicts Retreatment Failure in an Efficacy Study of Peginterferon-α-2a and Ribavirin in HIV/HCV Co-infected Patients

Baseline insulin resistance (HOMA-IR >2) was independently associated with failure to achieve sustained virological response during pegIFN-α-2a and ribavirin retreatment of HIV/HCV co-infected patient

Effect: decline; AOR 0.17; CI: 95% CI 0.05–0.64

Retreatment with pegIFN-α-2a and weight-based ribavirin achieved sustained virological response in 15% of HIV/HCV co-infected patients who had previously failed interferon-based therapy.

Effect: improvement; 15% SVR (14/96)

Insulin resistance was a better predictor of sustained virological response than steatosis or cirrhosis in multivariable models, and is the only non-invasive measure among the three correlated predict

Effect: improvement; IR model had smaller -2 log likelihood value than steatosis or cirrhosis models

Retreatment with pegIFN-α-2a and ribavirin was associated with significant cytopenias, dose reductions, and discontinuations, including 8% severe adverse events requiring discontinuation within the fi

Effect: adverse; 24% treatment discontinuation (23/96)