Explore ›
Finding
Finding
decline
Baseline insulin resistance (HOMA-IR >2) was independently associated with failure to achieve sustained virological response during pegIFN-α-2a and ribavirin retreatment of HIV/HCV co-infected patients, with a significant negative dose-response relationship between HOMA-IR categories and SVR rate.
| Effect size | AOR 0.17 |
| CI | 95% CI 0.05–0.64 |
| Follow-up | 48 weeks |
| Comparator | Patients without insulin resistance (HOMA-IR ≤2) |
| Effect summary | decline; AOR 0.17; CI: 95% CI 0.05–0.64 |
| Effect modifiers | [{"modifier": "HCV genotype", "interaction_p": "", "direction": "null", "stratum_details": "HCV genotype was not significantly associated with SVR in this retreatment population; genotype 1 subanalysis (n=81) showed IR remained the only independent predictor (AOR 0.16, 95% CI 0.04-0.67, p=0.01)", "plain_language": "The HCV genotype didn't change the insulin resistance-treatment response link. Even looking only at genotype 1 patients (the most common and hardest to treat), insulin resistance was still the strongest predictor.", "annotation_notes": "High prevalence of genotype 1 (85%) may have limited ability to detect genotype-IR interaction"}, {"modifier": "baseline log10 HCV RNA", "interaction_p": "not significant (interaction test p not reported as significant)", "direction": "null", "stratum_details": "HCV RNA was an independent co-predictor of SVR (AOR 0.36, 95% CI 0.14-0.93, p=0.04) but the interaction between IR and HCV RNA was not significant", "plain_language": "Both insulin resistance and viral load independently predict treatment failure -- they don't amplify each other. High viral load makes cure less likely regardless of insulin resistance status.", "annotation_notes": "Interaction between IR and HCV RNA explicitly tested and found non-significant"}] |
Connected entities
Interventions
Conditions
Outcomes
Source
PMC2994950
Insulin Resistance Predicts Retreatment Failure in an Efficacy Study of Peginterferon-α-2a and Ribavirin in HIV/HCV Co-infected Patients