PMC3073705

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO