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Finding
Finding
null
Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6; P=0.07) for whether a woman ovulated and 1.2 (95% CI: 0.7, 1.9; P=0.51) for number of ovulations.
| Effect size | ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation) |
| CI | 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0.7, 1.9) for number of ovulations |
| Follow-up | 6 months |
| Comparator | Placebo + identical lifestyle therapy (500 kcal/day deficit, 150 min/week exercise) |
| Effect summary | null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0.7, 1.9) for number of ovulations |
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Source
PMC3073705
The Effects of Metformin with Lifestyle Therapy in Polycystic Ovary Syndrome: A Randomized Double Blind Study