ExploreInterventionMetformin pamoate
Intervention

Metformin pamoate

Also known as: Metformin (titrated to 4 capsules/day) + lifestyle (500 kcal/day deficit, 150 min/week exercise) for 6 months Metformin embonate Metformin pamoate Metformin pamoate (substance)
21 findings 1 paper 11 related entities View in graph →

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outcomes
populations
studys

Findings (50)

None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
null

Adding metformin to lifestyle therapy did not significantly improve ovulation rates compared to placebo plus lifestyle in obese women with PCOS, with an ovulation rate ratio of 2.5 (95% CI: 0.9, 6.6;

Effect: null; ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of ovulations given ovulation); CI: 95% CI: (0.9, 6.6) for whether ovulated; 95% CI: (0

Size: ovulation rate ratio 2.5 (whether ovulated), 1.2 (number of CI: 95% CI: (0.9, 6.6) for whether ovulated;
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO
None
adverse

Metformin caused significantly more diarrhea and headaches compared to placebo, with 6 dropouts in the metformin arm due to medication side effects versus none in placebo, though metformin users had f

Effect: adverse; 6 MET dropouts for medication side effects vs 0 PBO

Size: 6 MET dropouts for medication side effects vs 0 PBO

Papers (1)