Association between fatigue and sleep disturbances during treatment for pediatric acute lymphoblastic leukemia and post-treatment neurocognitive performance

Children classified into a high fatigue and sleep disturbance profile during the first year of ALL therapy demonstrated significantly poorer post-treatment attention outcomes, including auditory susta

Effect: decline; mean difference = 11.33 (distractibility)

Children classified into a high fatigue and sleep disturbance profile during ALL therapy did not demonstrate significantly different post-treatment performance on executive function, processing speed,

Effect: null

Survivors of pediatric ALL treated with contemporary chemotherapy performed significantly below normative population means on measures of executive functioning, verbal short-term memory, visual sustai

Effect: decline; mean = 8.05 (NEPSY-II Response Set); CI: 95% CI: 6.60-9.49

Individual fatigue severity and sleep disturbance scores, evaluated at each assessment timepoint and as an overall average, were not consistent significant predictors of post-treatment measures of att

Effect: null