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Finding
Finding
decline
Children classified into a high fatigue and sleep disturbance profile during the first year of ALL therapy demonstrated significantly poorer post-treatment attention outcomes, including auditory sustained attention, distractibility, and verbal short-term memory, compared to children with mild fatigue and sleep disturbances.
| Effect size | mean difference = 11.33 (distractibility) |
| Follow-up | 1 year |
| Comparator | Class 1: mild fatigue and sleep disturbances during ALL treatment (50.8% of cohort, characterized by below-average fatigue T-scores and lower sleep disturbance scores) |
| Effect summary | decline; mean difference = 11.33 (distractibility) |
| Effect modifiers | [{"modifier": "sex", "interaction_p": "", "direction": "null", "stratum_details": "No evidence of sex-specific associations between patient-reported sleep and fatigue during treatment and neurocognitive outcomes (results not shown)", "plain_language": "Boys and girls were equally affected by the fatigue and sleep profile", "annotation_notes": "Cheung et al. found sex-specific associations in a prior study but this study did not replicate that finding."}] |
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Source
PMC8957586
Association between fatigue and sleep disturbances during treatment for pediatric acute lymphoblastic leukemia and post-treatment neurocognitive performance