Cardiorespiratory Fitness and Atherosclerotic Cardiovascular Outcomes by Levels of Baseline Predicted Cardiovascular Risk: The Look AHEAD Study

Among participants with type 2 diabetes and intermediate baseline predicted 10-year ASCVD risk (7.5%-20%), low cardiorespiratory fitness was associated with nearly twice the hazard of ASCVD events com

Effect: improvement; HR 1.94 (low vs high fitness); CI: 95% CI 1.12-3.35

Among participants with type 2 diabetes and low baseline predicted 10-year ASCVD risk (<7.5%), there was no statistically significant association between low cardiorespiratory fitness and ASCVD events

Effect: null; HR 1.53; CI: 95% CI 0.49-4.76

Among participants with type 2 diabetes and high baseline predicted 10-year ASCVD risk (>=20%), there was no statistically significant association between low cardiorespiratory fitness and ASCVD event

Effect: null; HR 1.40; CI: 95% CI 0.88-2.24

The association between cardiorespiratory fitness and incident ASCVD was significantly modified by baseline predicted 10-year ASCVD risk (P for interaction <0.001 for composite ASCVD, MI, and stroke),

Effect: improvement; P for interaction <0.001