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Finding
Finding
improvement
Among participants with type 2 diabetes and intermediate baseline predicted 10-year ASCVD risk (7.5%-20%), low cardiorespiratory fitness was associated with nearly twice the hazard of ASCVD events compared to high fitness (HR 1.94, 95% CI 1.12-3.35), with each 1-MET increment associated with a 16% lower risk of ASCVD (HR 0.84, 95% CI 0.74-0.95).
| Effect size | HR 1.94 (low vs high fitness) |
| CI | 95% CI 1.12-3.35 |
| Comparator | High cardiorespiratory fitness (>60th percentile on ACLS age- and sex-specific norms) |
| Effect summary | improvement; HR 1.94 (low vs high fitness); CI: 95% CI 1.12-3.35 |
| Effect modifiers | [{"modifier": "Baseline predicted 10-year ASCVD risk", "interaction_p": "P for interaction <0.001", "direction": "amplifies", "stratum_details": "Intermediate risk (7.5%-20%): HR 1.94 (1.12-3.35). Low risk (<7.5%): HR 1.53 (0.49-4.76). High risk (>=20%): HR 1.40 (0.88-2.24). Significant interaction for composite ASCVD, MI, and stroke separately.", "plain_language": "Fitness level mattered most for people with diabetes whose heart risk was in the middle range -- not too low, not too high. If your predicted 10-year risk was between 7.5% and 20%, being unfit nearly doubled your chances of a heart attack or stroke.", "annotation_notes": ""}] |
Connected entities
Interventions
Outcomes
Populations
Source
PMC8176653
Cardiorespiratory Fitness and Atherosclerotic Cardiovascular Outcomes by Levels of Baseline Predicted Cardiovascular Risk: The Look AHEAD Study