Outcomes associated with dual antiplatelet therapy after myocardial infarction in patients with aortic stenosis

Aortic stenosis was associated with a trend toward increased bleeding risk in MI patients treated with DAPT, but the combined meta-analysis result did not reach statistical significance, with signific

Effect: null; HR 1.59; CI: 95% CI 0.98-2.59

Aortic stenosis was significantly associated with an increased risk of recurrent myocardial infarction in MI patients treated with DAPT, with consistent results across Sweden and Denmark.

Effect: decline; HR 1.78; CI: 95% CI 1.25-2.54

Aortic stenosis was significantly associated with increased all-cause mortality in MI patients treated with DAPT, with approximately 2-fold increased risk in Sweden and 1.5-fold in Denmark.

Effect: decline; HR 1.76; CI: 95% CI 1.26-2.47

MI patients with aortic stenosis receiving both DAPT and oral anticoagulant therapy had substantially increased bleeding risk compared to MI patients without AS on DAPT alone, suggesting additive effe

Effect: adverse; HR 2.47; CI: 95% CI 1.56-3.90