Does higher starting dose of FSH stimulation with letrozole improve fertility preservation outcomes in women with breast cancer?

Higher starting dose of FSH with letrozole did not yield significantly more oocytes (13.3 +/- 8.7 vs 12.3 +/- 8.0) or embryos (6.3 +/- 4.7 vs 5.4 +/- 3.8) compared to low-dose FSH, despite producing m

Effect: null; 13.3 vs 12.3 oocytes (HD vs LD)

Live birth rate per embryo transfer trended higher in the low-dose FSH group (9/15, 60%) compared with the high-dose group (2/11, 18%, P=0.051), and ROC curve analysis validated 150 IU as the optimal

Effect: adverse; LBR 2/11 (18%) HD vs 9/15 (60%) LD