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Finding
Finding
improvement
Greater adherence to a healthful plant-based diet was associated with a 23% lower risk of ER-negative breast cancer, the strongest inverse association observed among all subtypes, robust to adjustment for total carotenoids, dietary fiber, and fruits and vegetables.
| Effect size | HR Q5 vs Q1 0.77 |
| CI | 95% CI 0.65, 0.90 |
| Comparator | Lowest quintile of hPDI adherence (Q1) |
| Effect summary | improvement; HR Q5 vs Q1 0.77; CI: 95% CI 0.65, 0.90 |
| Effect modifiers | [{"modifier": "Postmenopausal hormone use", "interaction_p": "p for interaction non-significant", "direction": "attenuates", "stratum_details": "Never/past PMH users: HR Q5vsQ1 0.69 (95%CI 0.54, 0.90; p-trend<0.01). Current users: weaker association.", "plain_language": "Women who never used or stopped using hormone therapy saw a stronger cancer-protective effect from a healthy plant-based diet, though the difference was not statistically definitive", "annotation_notes": "Suggestive but p for interaction was non-significant. Stronger association among never/past PMH users may reflect reduced hormonal masking of dietary effects."}, {"modifier": "Menopausal status", "interaction_p": "p for interaction non-significant", "direction": "null", "stratum_details": "Premenopausal HR 0.87 (95%CI 0.74, 1.02); postmenopausal HR 0.86 (95%CI 0.78, 0.95)", "plain_language": "The benefit applies whether you are pre- or post-menopausal", "annotation_notes": ""}, {"modifier": "Physical activity", "interaction_p": "p for interaction non-significant", "direction": "null", "stratum_details": "", "plain_language": "The benefit applies regardless of how active you are", "annotation_notes": ""}, {"modifier": "BMI", "interaction_p": "p for interaction non-significant", "direction": "null", "stratum_details": "", "plain_language": "The benefit applies regardless of your current weight", "annotation_notes": ""}] |
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Source
PMC8492491
Healthful and unhealthful plant-based diets and risk of breast cancer in U.S. women: results from the Nurses’ Health Studies