Diabetes mellitus among adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort Study

Adult survivors of childhood ALL had approximately twice the prevalence of T2DM compared to community controls after adjusting for age, sex, race, and education.

Effect: decline; OR 2.07; CI: 95% CI 1.11-3.87

Among childhood ALL survivors, those who developed drug-induced diabetes during treatment had nearly five-fold higher odds of type 2 diabetes in adulthood compared to those who did not develop DIDM, a

Effect: decline; OR 4.67; CI: 95% CI 2.53-8.61

Obese childhood ALL survivors (BMI >=30 kg/m2) had over seven-fold higher odds of T2DM compared to non-obese survivors, after adjusting for age, sex, race, education, physical activity, DIDM, and trea

Effect: decline; OR 7.40; CI: 95% CI 2.61-20.97

Among ALL survivors who were 15 years or older at diagnosis, every 1000 units/m2 increase in asparaginase dose increased the odds of developing drug-induced diabetes by 12%.

Effect: decline; OR 1.12 per 1000 units/m2; CI: 95% CI 1.02-1.23

Among ALL survivors who were younger than 15 years at diagnosis, each additional 1000 mg/m2 of dexamethasone exposure increased the odds of drug-induced diabetes during treatment by 58%.

Effect: decline; OR 1.58 per 1000 mg/m2; CI: 95% CI 1.05-2.37

Cranial radiation exposure was not associated with T2DM risk among adult survivors of childhood ALL, and stratifying by cranial radiation exposure did not modify the associations between other risk fa

Effect: null