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Finding
Finding
decline
Among ALL survivors who were 15 years or older at diagnosis, every 1000 units/m2 increase in asparaginase dose increased the odds of developing drug-induced diabetes by 12%.
| Effect size | OR 1.12 per 1000 units/m2 |
| CI | 95% CI 1.02-1.23 |
| Comparator | Lower asparaginase dose in ALL patients >=15 years at diagnosis |
| Effect summary | decline; OR 1.12 per 1000 units/m2; CI: 95% CI 1.02-1.23 |
| Adverse events | drug-induced diabetes mellitus 7.85%, 1.12 odds ratio per 1000 units/m2 increase |
| Effect modifiers | [{"modifier": "Age at ALL diagnosis (<15 vs >=15 years)", "interaction_p": "", "direction": "reverses", "stratum_details": "Asparaginase dose associated with DIDM only in children >=15 years at diagnosis, not in younger children. In younger children, dexamethasone dose was the significant predictor instead.", "plain_language": "Asparaginase dose only mattered for teenagers diagnosed at 15 or older \u2014 in younger children, it was the steroid dose that predicted drug-induced diabetes", "annotation_notes": "The paper stratified by age at diagnosis and found different drug predictors in each stratum."}] |
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Source
PMC6992468
Diabetes mellitus among adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort Study