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Finding
Finding
decline
Among ALL survivors who were younger than 15 years at diagnosis, each additional 1000 mg/m2 of dexamethasone exposure increased the odds of drug-induced diabetes during treatment by 58%.
| Effect size | OR 1.58 per 1000 mg/m2 |
| CI | 95% CI 1.05-2.37 |
| Comparator | Lower dexamethasone dose in ALL patients <15 years at diagnosis |
| Effect summary | decline; OR 1.58 per 1000 mg/m2; CI: 95% CI 1.05-2.37 |
| Effect modifiers | [{"modifier": "Age at ALL diagnosis (<15 vs >=15 years)", "interaction_p": "", "direction": "reverses", "stratum_details": "Dexamethasone dose associated with DIDM only in children <15 years at diagnosis, not in older children. In older children, asparaginase dose was the significant predictor instead.", "plain_language": "Steroid dose only mattered for younger children \u2014 in teenagers 15 and older, it was the asparaginase dose that predicted drug-induced diabetes", "annotation_notes": "Complementary to the asparaginase finding. Different drugs drive DIDM risk at different ages."}] |
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Outcomes
Populations
Source
PMC6992468
Diabetes mellitus among adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort Study