A multimodal rehabilitation program for patients with ICU acquired weakness improves ventilator weaning and discharge home ☆

The addition of a progressive multimodal rehabilitation program to usual care physical therapy significantly improved ventilator weaning success in ICU survivors with acquired weakness, with 87% of th

Effect: improvement; 87% vs. 41%

A significantly higher proportion of patients in the multimodal rehabilitation program plus usual care group were discharged home compared to the usual care group in ICU survivors with acquired weakne

Effect: improvement; 53% vs. 12%

Despite numerically greater improvements in handgrip strength, gait speed, and 6-minute walk distance in the MRP+UC group compared to usual care, none of these between-group differences in functional

Effect: null; handgrip change 3.6 vs 1.3 kg (p=0.20); gait speed change 0.13 vs 0.07 m/s (p=0.41); 6MWD change 40.6 vs 19.9 ft (p=0.33); SPPB change 1.1 vs 1.

Regardless of treatment group, patients who achieved greater improvements in functional measures including handgrip strength, gait speed, 6MWD, and ambulation were significantly more likely to wean fr

Effect: improvement; OR 1.45 (SPPB), OR 2.19 (basic mobility)