Blood Pressure and Outcomes in Very Old Hypertensive Coronary Artery Disease Patients: An INVEST Substudy

The relationship between on-treatment systolic blood pressure and primary outcome in very old hypertensive CAD patients follows a J-shaped curve, with the hazard ratio nadir at 140 mm Hg -- higher tha

Effect: mixed; HR nadir at SBP 140 mm Hg for very old (vs 110 mm Hg for aged <60 and 60-<70, and 135 mm Hg for aged 70-<80)

The relationship between on-treatment diastolic blood pressure and primary outcome in very old hypertensive CAD patients follows a J-shaped curve, with the hazard ratio nadir at 70 mm Hg -- somewhat l

Effect: mixed; HR nadir at DBP 70 mm Hg for very old (vs 75 mm Hg for all other age groups)

There was no difference in the primary outcome between verapamil SR-based and atenolol-based treatment strategies for any age group, including the very old.

Effect: null; No difference (Figure 4)

The very old had the highest proportion of primary outcome events (23.6%, P<.001) among all age groups, driven by all-cause death, with increasing age also associated with a shift toward more fatal ev

Effect: decline; 23.6% primary outcome rate in very old