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Finding
Finding
mixed
The relationship between on-treatment systolic blood pressure and primary outcome in very old hypertensive CAD patients follows a J-shaped curve, with the hazard ratio nadir at 140 mm Hg -- higher than the nadir for younger age groups (110-135 mm Hg), suggesting that lowering systolic pressure below 140 mm Hg in this population increases risk.
| Effect size | HR nadir at SBP 140 mm Hg for very old (vs 110 mm Hg for aged <60 and 60-<70, and 135 mm Hg for aged 70-<80) |
| Comparator | Same cohort at different on-treatment systolic blood pressure levels (reference SBP = 140 mm Hg, HR = 1.0) |
| Effect summary | mixed; HR nadir at SBP 140 mm Hg for very old (vs 110 mm Hg for aged <60 and 60-<70, and 135 mm Hg for aged 70-<80) |
| Effect modifiers | [{"modifier": "age group", "interaction_p": "P<.001", "direction": "amplifies", "stratum_details": "SBP at HR nadir: <60yr = 110 mmHg; 60-<70yr = 110 mmHg; 70-<80yr = 135 mmHg; >=80yr = 140 mmHg", "plain_language": "The older you are, the more dangerous it is to push systolic blood pressure too low -- the 'safe floor' moves up with age", "annotation_notes": "Progressive increase in SBP nadir with age. The biggest jump is between 60-<70 (110 mmHg) and 70-<80 (135 mmHg)."}] |
Connected entities
Interventions
Conditions
Outcomes
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Source
PMC3008373
Blood Pressure and Outcomes in Very Old Hypertensive Coronary Artery Disease Patients: An INVEST Substudy