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Finding
Finding
improvement
Greater adherence to a healthful plant-based diet (hPDI) was associated with a modest but significant reduction in total invasive breast cancer risk, independent of weight change, total carotenoid intake, and dietary fiber.
| Effect size | HR Q5 vs Q1 0.89 |
| CI | 95% CI 0.83, 0.94 |
| Follow-up | decades |
| Comparator | Lowest quintile of hPDI adherence (Q1) |
| Effect summary | improvement; HR Q5 vs Q1 0.89; CI: 95% CI 0.83, 0.94 |
| Effect modifiers | [{"modifier": "Estrogen receptor status", "interaction_p": "p-heterogeneity=0.01", "direction": "attenuates", "stratum_details": "ER-negative HR 0.77 (95% CI 0.65-0.90) vs total BC HR 0.89 (95% CI 0.83-0.94)", "plain_language": "The protective effect of a healthy plant-based diet is stronger against ER-negative breast cancers than breast cancer overall", "annotation_notes": "Significant heterogeneity by ER status. The inverse association was stronger for ER-negative tumors, indicating ER status modifies the effect magnitude."}, {"modifier": "Menopausal status", "interaction_p": "p for interaction non-significant", "direction": "null", "stratum_details": "Premenopausal HR 0.87 (95%CI 0.74, 1.02); postmenopausal HR 0.86 (95%CI 0.78, 0.95)", "plain_language": "The benefit of a healthy plant-based diet applies whether you are pre- or post-menopausal", "annotation_notes": ""}, {"modifier": "BMI", "interaction_p": "p for interaction non-significant", "direction": "null", "stratum_details": "", "plain_language": "The benefit applies regardless of your current weight", "annotation_notes": ""}, {"modifier": "Physical activity", "interaction_p": "p for interaction non-significant", "direction": "null", "stratum_details": "", "plain_language": "The benefit applies regardless of how active you are", "annotation_notes": ""}] |
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Source
PMC8492491
Healthful and unhealthful plant-based diets and risk of breast cancer in U.S. women: results from the Nurses’ Health Studies