PMC7863698

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)

ESRT-1 significantly improved mindfulness scores in surgical PGY-1 residents compared to active controls at both post-intervention and 50-week follow-up, with large effect sizes.

Effect: improvement; Cohen d = 1.03 (post), Cohen d = 0.78 (50-wk)