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Finding
Finding
improvement
Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent with reduced sympathetic nervous system activation.
| Effect size | NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048 |
| CI | NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI (0.54, 0.97); CREB: 95% CI (0.40, 0.99) |
| Comparator | Pooled active controls from both trials |
| Effect summary | improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI (0.54, 0.97); CREB: 95% CI (0.40, 0.99) |
Connected entities
Interventions
Conditions
Source
PMC7863698
Enhanced Stress Resilience Training in Surgeons Iterative Adaptation and Biopsychosocial Effects in 2 Small Randomized Trials