Explore › Outcome › Conserved transcriptional response to adversity (CTRA)
Outcome

Conserved transcriptional response to adversity (CTRA)

Also known as: Conserved transcriptional response to adversity (CTRA) — pro-inflammatory signaling pathway activity (NF-kB, AP-1, CREB, ISRE)
3 findings 1 paper 3 related entities View in graph →

Related entities

interventions
ESRT1
conditions
pro-inflammatory gene expression1
studys
PMC78636981

Findings (27)

None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →
None
improvement

Pooled ESRT participants showed a significant 26-37% relative reduction in activity of three stress-stimulated pro-inflammatory signaling pathways (NF-kB, AP-1, CREB) compared to controls, consistent

Effect: improvement; NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold, p = 0.031; CREB: 0.63-fold, p = 0.048; CI: NF-kB: 95% CI (0.56, 0.99); AP-1

Size: NF-kB: 0.74-fold relative change, p = 0.043; AP-1: 0.73-fold CI: NF-kB: 95% CI (0.56, 0.99); AP-1: 95% CI
PMC7863698
Finding details → · Paper → · Graph →

Papers (1)