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composite cardiometabolic risk score

Also known as: composite cardiometabolic risk score (summed z-scores of visceral fat, blood pressure, HOMA-IR, triglyceride:HDL ratio, leptin:adiponectin ratio) at age 12 composite cardiometabolic risk score at age 12 in relation to all gestational PFAS (PFOA, PFOS, PFNA, PFHxS) and their mixture composite cardiometabolic risk score at age 12 in relation to gestational PFOS, PFHxS, and PFNA composite cardiometabolic risk score, HOMA-IR, and visceral fat area at age 12 in relation to gestational PFAS mixture BP
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Findings (50)

None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
improvement

Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among

Effect: improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA)

Size: β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,
None
null

Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the

Effect: null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA)

Size: B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7,

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