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Finding
Finding
improvement
Physical activity significantly modified the association between gestational PFOA and cardiometabolic risk scores at age 12: each doubling of PFOA was associated with worse cardiometabolic risk among less active children (β:1.4; 95% CI:0.5, 2.2) but not among more active children (β:−0.2; 95% CI:−1.2, 0.7), with a significant interaction (p=0.01).
| Effect size | β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA |
| CI | 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA) |
| Comparator | Children with PAQ-C scores below median (<2.65) who had gestational PFOA exposure |
| Effect summary | improvement; β: −0.2 (high PA) vs β: 1.4 (low PA) per doubling of PFOA; CI: 95% CI: −1.2, 0.7 (high PA); 95% CI: 0.5, 2.2 (low PA) |
| Effect modifiers | [{"modifier": "Actigraphy-based MVPA (accelerometer minutes of moderate-vigorous physical activity per day)", "interaction_p": "0.33", "direction": "null", "stratum_details": "\u226491 min MVPA/day: \u03b2: 1.1 (95% CI: 0.2, 2.1); >91 min MVPA/day: \u03b2: 0.5 (95% CI: \u22120.6, 1.5). Similar pattern to PAQ-C but attenuated and not statistically significant.", "plain_language": "Accelerometer-measured activity showed the same pattern as self-reported activity \u2014 less active kids had worse PFOA effects \u2014 but the difference was not statistically significant.", "annotation_notes": "PAQ-C and MVPA were only modestly correlated (Spearman r=0.17, p<0.05). PAQ-C captures type and routine of activity; MVPA captures frequency, time, and intensity."}, {"modifier": "Diet quality (Healthy Eating Index score)", "interaction_p": "not significant (specific p-value not reported for individual PFAS; mixture HEI interaction p=0.94)", "direction": "null", "stratum_details": "HEI \u226550 vs <50 did not modify associations of any PFAS with cardiometabolic risk scores.", "plain_language": "Diet quality did not change whether PFOA exposure harmed kids or not \u2014 only physical activity mattered.", "annotation_notes": ""}] |
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Outcomes
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Source
PMC9637371
Physical Activity Modifies the Relation Between Gestational Perfluorooctanoic Acid Exposure and Adolescent Cardiometabolic Risk