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Finding
Finding
null
Physical activity showed a suggestive but non-significant pattern of modifying the PFAS mixture-cardiometabolic association: cardiometabolic risk scores increased by 0.7 units per IQR increase in the PFAS mixture among less active children but were null among more active children, though the interaction was not statistically significant (p=0.17).
| Effect size | B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture |
| CI | 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA) |
| Comparator | Children with high PAQ-C scores (≥2.65) who had gestational PFAS mixture exposure |
| Effect summary | null; B: 0.7 (low PA) vs B: 0.0 (high PA) per IQR increase in PFAS mixture; CI: 95% CI: 0.0, 1.3 (low PA); 95% CI: −0.7, 0.7 (high PA) |
| Effect modifiers | [{"modifier": "MVPA (accelerometer-based)", "interaction_p": "0.83", "direction": "null", "stratum_details": "MVPA did not modify PFAS mixture-cardiometabolic association.", "plain_language": "Accelerometer-measured activity did not change the mixture effect.", "annotation_notes": ""}, {"modifier": "Diet quality (HEI score)", "interaction_p": "0.94", "direction": "null", "stratum_details": "HEI did not modify PFAS mixture-cardiometabolic association.", "plain_language": "Diet quality did not change the mixture effect.", "annotation_notes": ""}] |
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Source
PMC9637371
Physical Activity Modifies the Relation Between Gestational Perfluorooctanoic Acid Exposure and Adolescent Cardiometabolic Risk