The impact of pre-apheresis Health Related Quality of Life on peripheral blood progenitor cell yield and donor’s health and outcome: Secondary analysis of Patient-Reported Outcome Data from the RDSafe and BMT CTN 0201 Clinical Trials

Related PBSC donors with pre-donation PCS scores in the highest quartile were significantly less likely to report grade 2-4 pain at 1 month post-donation compared with donors with PCS scores in the lo

Effect: decline; OR 0.1; CI: 95% CI 0.01-0.83

Pre-donation mental health status (MCS score), depression, and anxiety levels were not significantly associated with donation-associated pain and toxicities at any time point post-donation in related

Effect: null

Neither pre-donation physical nor mental component summary scores were associated with post-donation grade 2-4 pain or toxicities at any time point in unrelated PBSC donors.

Effect: null

There was no correlation between pre-donation physical or mental component summary HRQoL scores and peripheral blood stem cell collection yield in either related or unrelated donors.

Effect: null

There was a weak negative correlation between pre-donation anxiety and PBSC stem cell yield in related donors, though this did not meet the study's pre-specified significance threshold of p=0.01.

Effect: null; r=−0.29