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Finding
Finding
decline
Related PBSC donors with pre-donation PCS scores in the highest quartile were significantly less likely to report grade 2-4 pain at 1 month post-donation compared with donors with PCS scores in the lowest quartile, and this association persisted in multivariable analysis controlling for donor and procedure characteristics.
| Effect size | OR 0.1 |
| CI | 95% CI 0.01-0.83 |
| Follow-up | 1 year |
| Comparator | Related donors with pre-donation PCS score in the lowest quartile |
| Effect summary | decline; OR 0.1; CI: 95% CI 0.01-0.83 |
| Adverse events | grade 2-4 pain 1 month 0% (highest quartile) vs 10% (lowest quartile) |
| Effect modifiers | [{"modifier": "age (majority of donors with PCS < 45 were aged 60+)", "interaction_p": "", "direction": "amplifies", "stratum_details": "11 of 12 RDs with PCS < 45 were aged 60+", "plain_language": "Older donors were more likely to have low PCS scores and higher post-donation pain, suggesting age amplifies the PCS-pain association", "annotation_notes": "Not a formal interaction test but a notable descriptive finding. Previous studies confirm older donors have more persistent post-donation pain."}] |
Connected entities
Interventions
Conditions
Outcomes
Source
PMC9427696
The impact of pre-apheresis Health Related Quality of Life on peripheral blood progenitor cell yield and donor’s health and outcome: Secondary analysis of Patient-Reported Outcome Data from the RDSafe and BMT CTN 0201 Clinical Trials