Effects of Androgen Deprivation Therapy on Pain Perception, Quality-of-Life and Depression in Men with Prostate Cancer

Androgen deprivation therapy in men with prostate cancer was not associated with changes in clinical pain (BPI), pressure pain thresholds, cold pain tolerance, mechanical pain temporal summation, or c

Effect: null; 0.31; CI: 95% CI = -0.55 to 1.17

Androgen deprivation therapy in men with prostate cancer was associated with statistically significant worsening of depression scores on the PHQ-9 over 6 months compared to eugonadal controls.

Effect: adverse; 0.93; CI: 95%CI= 0.04 to 1.82

Men undergoing ADT experienced statistically significant worsening in physical role limitation quality of life compared to eugonadal controls, while other QOL domains (emotional well-being, emotional

Effect: adverse; -18.28; CI: 95%CI= -30.18 to -6.37

Men undergoing ADT displayed a trend toward worsening anxiety as assessed by STAI state scores that did not reach statistical significance, while STAI trait scores showed no change.

Effect: null; 2.34; CI: 95% CI = -0.09 to 4.76

ADT was not associated with changes in pain catastrophizing composite scores or any subdomain (helplessness, magnification, rumination) compared to eugonadal controls.

Effect: null; -0.19; CI: 95% CI = -2.59 to 2.21