Depression in Parkinson’s disease: Symptom Improvement and Residual Symptoms Following Acute Pharmacological Management

Treatment responders with depression in Parkinson's disease demonstrated significant improvement on the HAM-D core mood subscale compared to nonresponders after 8 weeks of antidepressant treatment.

Effect: improvement; Cohen's d= 1.52

Treatment responders with depression in Parkinson's disease demonstrated significant improvement on the HAM-D anxiety subscale compared to nonresponders after 8 weeks of antidepressant treatment.

Effect: improvement; Cohen's d=.96

Treatment responders with depression in Parkinson's disease demonstrated significant improvement on the HAM-D insomnia subscale compared to nonresponders after 8 weeks of antidepressant treatment.

Effect: improvement; Cohen's d=.94

Treatment responders with depression in Parkinson's disease demonstrated significant improvement on the HAM-D somatic subscale compared to nonresponders after 8 weeks of antidepressant treatment, incl

Effect: improvement; Cohen's d= 1.30

Despite meeting criteria for treatment response, more than 50% of responders continued to report residual depressed mood, lack of interest, psychic anxiety, and low energy at week 8, though symptoms w

Effect: mixed

The nature of baseline depressive symptoms in PD was unrelated to motor aspects of PD including disease duration, Hoehn and Yahr stage, and UPDRS motor score.

Effect: null