Paperspregnancy2782481

Mortality and virologic outcomes following access to antiretroviral therapy among a cohort of HIV-infected women who received single-dose nevirapine in Lusaka, Zambia

Journal of acquired immune deficiency syndromes (1999) · 1-9-2009 · 2782481 on PMC →
Entities in this paper
Patient Access to Records NNRTI-based ART initiation HIV screening NNRTI-based ART HIV infection All-cause mortality Sustained Viral Suppression Proportion of uterus Retention in Care

Extracted findings (4)

Access to an NNRTI-based ART program more than halved mortality among a cohort of HIV-infected women who had previously received single-dose nevirapine for PMTCT, with the reduction remaining signific

Effect: improvement; RH = 0.46; CI: 95% CI: 0.23-0.91

Size: RH = 0.46 CI: 95% CI: 0.23-0.91

Among SDNVP-exposed women initiating NNRTI-based ART, the proportion achieving viral suppression increased significantly with longer time since SDNVP exposure, from 37.5% at <6 months to 77.1% at >24

Effect: improvement; chi-square trend p=0.01

Size: chi-square trend p=0.01
HIV screening
improvement

Among 1,378 HIV-infected women enrolled during pregnancy, 38.3% met ART eligibility criteria (CD4 <200 or <350 with WHO stage III) during pregnancy, and this group had 23.7% mortality by 24 months in

Effect: improvement; 38.3%

Size: 38.3%
NNRTI-based ART
decline

Less than half of HIV-infected women who were in need of ART actually received it when offered, with attrition occurring at screening uptake (20% refused), ART initiation (20% of eligible did not star

Effect: decline