Explore ›
Finding
Finding
improvement
Hispanic children under 10 years of age treated for ALL on DFCI 05-001 had a significantly lower cumulative incidence of bone fracture compared to non-Hispanic patients, remaining significant in multivariable modeling.
| Effect size | HR 0.24 |
| CI | 95% CI 0.10-0.54 |
| Comparator | Non-Hispanic children aged < 10 years treated on the same DFCI 05-001 protocol |
| Effect summary | improvement; HR 0.24; CI: 95% CI 0.10-0.54 |
| Effect modifiers | [{"modifier": "age (< 10 years vs >= 10 years)", "interaction_p": "", "direction": "amplifies", "stratum_details": "Age < 10: HR 0.24 (0.10-0.54), p=0.0006. Age >= 10: HR 0.63 (0.31-1.28), p=0.20. Significant ethnicity effect only in younger children.", "plain_language": "The lower fracture rate in Hispanic children was seen only in younger children (under 10), not older ones", "annotation_notes": "Opposite age pattern from osteonecrosis finding."}, {"modifier": "obesity", "interaction_p": "", "direction": "null", "stratum_details": "No detectable difference in cumulative incidence of fracture by obesity for each age group", "plain_language": "Being obese did not affect fracture risk in this cohort", "annotation_notes": ""}] |
Connected entities
Interventions
Conditions
Outcomes
Populations
Source
PMC5766393
An investigation of toxicities and survival in Hispanic children and adolescents with ALL: Results from the Dana-Farber Cancer Institute ALL Consortium protocol 05-001