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Finding
Finding
improvement
Hispanic patients aged 10 years and older treated for ALL on DFCI 05-001 had a significantly lower cumulative incidence of osteonecrosis compared to non-Hispanic patients, remaining significant in multivariable modeling adjusting for sex, asparaginase randomization, and risk group.
| Effect size | HR 0.28 |
| CI | 95% CI 0.10-0.76 |
| Comparator | Non-Hispanic children aged >= 10 years treated on the same DFCI 05-001 protocol |
| Effect summary | improvement; HR 0.28; CI: 95% CI 0.10-0.76 |
| Effect modifiers | [{"modifier": "age (>= 10 years vs < 10 years)", "interaction_p": "p<0.0001 for age effect on ON overall", "direction": "amplifies", "stratum_details": "Age >= 10: HR 0.28 (0.10-0.76), p=0.013. Age < 10: HR 0.61 (0.18-2.02), p=0.41. Significant ethnicity effect only in older children.", "plain_language": "The protective effect of Hispanic ethnicity on osteonecrosis was seen only in older children (age 10+), not younger ones", "annotation_notes": ""}, {"modifier": "obesity", "interaction_p": "", "direction": "null", "stratum_details": "No detectable difference in cumulative incidence of ON by obesity for each age group", "plain_language": "Being obese did not affect osteonecrosis risk in this cohort", "annotation_notes": ""}] |
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Outcomes
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Source
PMC5766393
An investigation of toxicities and survival in Hispanic children and adolescents with ALL: Results from the Dana-Farber Cancer Institute ALL Consortium protocol 05-001