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Finding
Finding
decline
Animals exposed to LCS exhibited impaired glucose tolerance, decreased insulin sensitivity, elevated fasting glucose, hyperinsulinemia, and impaired GLP-1 release — effects that sometimes occurred even in the absence of increased weight gain.
| Effect size | fasting glucose levels 1.6-fold higher in ASP-exposed vs controls; 2.25- and 2.3-fold higher for males and females in ASP+MSG vs controls; insulin levels double those in plain-water control group in NNS-exposed mice |
| Comparator | Plain water controls or calorically-sweetened controls |
| Effect summary | decline; fasting glucose levels 1.6-fold higher in ASP-exposed vs controls; 2.25- and 2.3-fold higher for males and females in ASP+MSG vs controls; insulin levels double those in plain-water control group in NNS-exposed mice |
| Adverse events | impaired glucose tolerance, decreased insulin sensitivity, elevated fasting glucose, hyperinsulinemia, impaired GLP-1 release |
Connected entities
Conditions
Outcomes
Source
PMC5045440
Low-calorie sweetener use and energy balance: Results from experimental studies in animals, and large-scale prospective studies in humans