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Finding
Finding
decline
For every 30-unit increase in energy-adjusted glycemic load, Whites had a 1.11-fold increased risk of incident coronary heart disease over 17 years of follow-up.
| Effect size | HR 1.11 |
| CI | 95% CI:1.01, 1.21 |
| Follow-up | 17 years |
| Comparator | Lower glycemic load diet (continuous, per 30-unit decrease in energy-adjusted GL) |
| Effect summary | decline; HR 1.11; CI: 95% CI:1.01, 1.21 |
| Effect modifiers | [{"modifier": "Diabetes status", "interaction_p": "", "direction": "attenuates", "stratum_details": "In Whites without diabetes, GL was significantly associated with CHD (HR 1.14, 95% CI 1.02-1.26), but in Whites with diabetes the relationship was not significant. The interaction between GL and diabetes status was not statistically significant, but the pattern in stratified analyses suggests the GL-CHD association is driven by those without diabetes.", "plain_language": "The link between high glycemic load diet and heart disease was mainly seen in White adults without diabetes; in those who already had diabetes, the effect was not significant", "annotation_notes": "The overall finding in Whites is significant (HR 1.11). The stratified result in Whites without diabetes (HR 1.14) survived Bonferroni correction at p < 0.025. The formal interaction test was not significant, so direction is technically 'attenuates' based on the pattern rather than a confirmed interaction."}] |
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Source
PMC3085981
Association of glycemic index and glycemic load with risk of incident coronary heart disease among Whites and African Americans with and without type 2 diabetes: The Atherosclerosis Risk in Communities Study