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pharmacotherapy for opioid use disorder

Also known as: pharmacotherapy for opioid use disorder (methadone maintenance or buprenorphine) during postpartum period pharmacotherapy for opioid use disorder (methadone or buprenorphine) at 7-12 months postpartum
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Findings (50)

None
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At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
null

At 7-12 months postpartum, opioid overdose rates increased for both women receiving pharmacotherapy and those not receiving treatment, suggesting the protective effect of pharmacotherapy waned in the

Effect: null; 12.3 per 100,000 person-days (overall rate at 7-12 months postpartum); CI: 95% CI 9.9-15.0

Size: 12.3 per 100,000 person-days (overall rate at 7-12 months po CI: 95% CI 9.9-15.0
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9
None
improvement

Women receiving pharmacotherapy with methadone or buprenorphine had statistically significantly lower opioid overdose rates compared to women not receiving pharmacotherapy at 4-6 months postpartum (1.

Effect: improvement; 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 100,000 person-days not on pharmacotherapy at 4-6 months postpartum; CI: 95% C

Size: 1.3 per 100,000 person-days on pharmacotherapy vs 10.7 per 1 CI: 95% CI 0.16-4.74 (on pharmacotherapy); 9

Papers (1)