E-selectin level

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both

Effect: null; non-significant in both ILS and metformin groups

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34

Higher baseline sE-selectin was the most robust biomarker predictor of incident diabetes in the placebo group, remaining significant after adjustment for traditional diabetes risk factors, 1-year chan

Effect: decline; HR 1.19; CI: 95% CI 1.06, 1.34