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Finding
Finding
null
The strong association between baseline sE-selectin and incident diabetes seen in the placebo group was completely absent in both the lifestyle and metformin intervention groups, suggesting that both active interventions disconnect the endothelial dysfunction-diabetes link.
| Effect size | non-significant in both ILS and metformin groups |
| Comparator | per 1 SD increase in baseline sE-selectin (ILS and metformin groups vs placebo) |
| Effect summary | null; non-significant in both ILS and metformin groups |
| Effect modifiers | [{"modifier": "treatment group (ILS/metformin vs placebo)", "interaction_p": "heterogeneity by group present", "direction": "attenuates", "stratum_details": "sE-selectin HR 1.19 (1.06-1.34) in placebo vs non-significant in ILS and metformin groups", "plain_language": "The link between high sE-selectin and diabetes risk disappeared completely when people were on lifestyle or metformin treatment.", "annotation_notes": "Significant heterogeneity confirmed. Both ILS and metformin disconnected the sE-selectin-diabetes association. Authors interpret this as evidence that endothelial dysfunction is not a direct driver of diabetes -- it may reflect shared vascular-metabolic soil."}] |
Connected entities
Interventions
Conditions
Outcomes
Source
PMC6456055
Non-traditional biomarkers and incident diabetes in the Diabetes Prevention Program: comparative effects of lifestyle and metformin interventions