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Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial

Early human development · 01-6-2022 · 9516351 on PMC →
Entities in this paper
Omega 3-6-9 fatty acid supplementation RCADS (Revised Children's Anxiety and Depression Scale) total anxiety and depression subscale internalizing behavior problems impaired interpersonal relationship skills externalizing behavior problems Autism spectrum disorder Anxious/depressed behavior score Internalizing problems Interpersonal relationship finding Externalizing behaviors Sleep outcomes

Extracted findings (5)

Children randomized to omega 3-6-9 supplementation for 90 days experienced a medium magnitude reduction in anxious and depressed behaviors compared to canola oil placebo, as reported by caregivers on

Effect: improvement; Δ Difference = −1.27, d = −0.58

Size: Δ Difference = −1.27, d = −0.58

Children randomized to omega 3-6-9 supplementation for 90 days experienced a medium magnitude reduction in internalizing behaviors (emotionally reactive, anxious/depressed, somatic complaints, withdra

Effect: improvement; Δ Difference = −3.41, d = −0.68

Size: Δ Difference = −3.41, d = −0.68

Children randomized to omega 3-6-9 supplementation for 90 days experienced a large magnitude improvement in interpersonal relationship skills compared to canola oil placebo, reaching an 'adequate' ada

Effect: improvement; Δ Difference = 7.50, d = 0.83

Size: Δ Difference = 7.50, d = 0.83

Omega 3-6-9 supplementation for 90 days had no statistically significant effect on externalizing behaviors or CBCL DSM-oriented scales (affective, anxiety, pervasive developmental, ADHD, oppositional

Effect: null

Omega 3-6-9 supplementation for 90 days had no statistically significant effect on any sleep outcome (CSHQ domains or BISQ measures) compared to placebo.

Effect: null