Preconception Substance Use and Risk of Unintended Pregnancy: Pregnancy Risk Assessment Monitoring System 2016–17

Preconception cigarette smoking was significantly associated with increased odds of unintended pregnancy, with heavier smoking showing a stronger association.

Effect: decline; AOR: 1.5; CI: 95% CI: 1.4–1.6

Preconception heavy alcohol consumption and binge drinking were significantly associated with increased odds of unintended pregnancy, while the dichotomous measure of any alcohol consumption showed no

Effect: decline; AOR: 1.9; CI: 95% CI: 1.5–2.2

Preconception cannabis use was significantly associated with nearly doubled odds of unintended pregnancy.

Effect: decline; AOR: 1.9; CI: 95% CI: 1.5–2.3

Preconception use of illicit or recreational drugs was significantly associated with increased odds of unintended pregnancy.

Effect: decline; AOR: 1.7; CI: 95% CI: 1.2–2.4

Preconception use of nicotine/tobacco products other than cigarettes was significantly associated with increased odds of unintended pregnancy.

Effect: decline; AOR: 1.4; CI: 95% CI: 1.3–1.5

Preconception prescription opioid use was significantly associated with increased odds of unintended pregnancy.

Effect: decline; AOR: 1.4; CI: 95% CI: 1.02–1.9

Preconception prescription antidepressant use was significantly associated with increased odds of unintended pregnancy overall, though the association with unwanted pregnancy subtype specifically was

Effect: decline; AOR: 1.8; CI: 95% CI: 1.1–3.0

Preconception over-the-counter pain relief use was significantly associated with increased odds of unintended pregnancy.

Effect: decline; AOR: 1.4; CI: 95% CI: 1.2–1.6