Early Weight Loss Success Identifies Nonresponders following a Lifestyle Intervention in a Worksite Diabetes Prevention Trial

A 16-week DPP-adapted lifestyle intervention produced progressive weight loss, with 53% of prediabetic participants achieving >= 5% clinically significant weight loss.

Effect: improvement; -2.0% +/- 1.2% at week 5

Failure to achieve 2.5% weight loss by week 5 of a DPP-adapted lifestyle intervention was strongly predictive of failure to achieve >= 5% weight loss at 4 months, with only 11.1% of those below thresh

Effect: improvement; OR 14.6; CI: 95% CI: 1.4-138.2

Failure to achieve 2.5% weight loss by week 5 of a DPP-adapted lifestyle intervention was strongly predictive of failure to achieve >= 5% weight loss at 7 months, with only 12.5% of those below thresh

Effect: improvement; OR 8.0; CI: 95% CI: 1.3-48.2

Age, gender, and BMI were not significant predictors of weight loss at months 4 or 7 following a DPP-adapted lifestyle intervention in prediabetic adults.

Effect: null

Weight change at weeks 2 and 3 of the intervention was not significantly associated with weight change at months 4 or 7, meaning very early weight loss is not useful for identifying nonresponders.

Effect: null