Neurobehavioral Concerns among Males with Dystrophinopathy Using Population-Based Surveillance Data from the Muscular Dystrophy Surveillance, Tracking, and Research Network

Corticosteroid use was associated with a significantly higher risk of behavior problems among males with dystrophinopathy, with the hazard of behavior problems being 2.4 times higher during years in w

Effect: adverse; HR=2.35; CI: 95%CI=1.75,3.16

Use of a mobility device was associated with a 53% higher risk of behavior problems among males with dystrophinopathy.

Effect: decline; HR=1.53; CI: 95%CI=1.06,2.21

Use of a mobility device was associated with a 3.5-fold higher risk of depressed mood among males with dystrophinopathy.

Effect: decline; HR=3.53; CI: 95%CI=2.13,5.85

Corticosteroid use was not significantly associated with ADHD among males with dystrophinopathy, suggesting that ADHD may be part of the dystrophinopathy neurocognitive phenotype independent of treatm

Effect: null

Use of a mobility device was not significantly associated with ADHD among males with dystrophinopathy.

Effect: null

Corticosteroid use was not significantly associated with depressed mood among males with dystrophinopathy in the primary analysis.

Effect: null