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Finding
Finding
null
Intensive blood pressure control targeting systolic BP <120 mmHg did not significantly reduce total stroke incidence compared to standard control targeting <140 mmHg over mean 3.33 years follow-up in SPRINT (69 vs 78 strokes).
| Effect size | 69 vs 78 strokes |
| Follow-up | 3.33 years |
| Comparator | Standard blood pressure control (systolic BP target <140 mmHg), achieved mean SBP 136.2 mmHg at one year |
| Effect summary | null; 69 vs 78 strokes |
| Effect modifiers | [{"modifier": "Baseline cardiovascular disease status", "interaction_p": "p=0.05", "direction": "null", "stratum_details": "No prior CVD: intensive 43 strokes vs standard 61 strokes (p=0.09). Interaction between baseline CVD status and treatment arm on stroke risk p=0.05, did not meet pre-defined Hommel-adjusted significance threshold.", "plain_language": "There was a suggestive trend that people without prior heart disease may benefit more from aggressive blood pressure lowering for stroke prevention, but it didn't reach statistical significance.", "annotation_notes": "The interaction p=0.05 is borderline but did not meet the pre-specified Hommel-adjusted alpha for significance. Reported in Figure 2."}, {"modifier": "Age (<75 vs >=75 years)", "interaction_p": "", "direction": "null", "stratum_details": "Treatment effects were similar across age strata (p=0.05, Figure 2)", "plain_language": "Age did not change the effect of intensive blood pressure lowering on stroke risk.", "annotation_notes": "Figure 2 subgroup analysis."}, {"modifier": "Sex", "interaction_p": "", "direction": "null", "stratum_details": "Treatment effects were similar across sex strata (Figure 2)", "plain_language": "Being male or female did not change the effect of intensive blood pressure lowering on stroke risk.", "annotation_notes": "Figure 2 subgroup analysis."}, {"modifier": "Race/ethnicity", "interaction_p": "", "direction": "null", "stratum_details": "Treatment effects were similar across race/ethnic strata (Figure 2)", "plain_language": "Race and ethnicity did not change the effect of intensive blood pressure lowering on stroke risk.", "annotation_notes": "Figure 2 subgroup analysis."}] |
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Source
PMC8224947
Effect of Intensive Versus Standard Blood Pressure Control on Stroke Subtypes