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Finding
Finding
improvement
Multiple myeloma patients with higher pre-diagnosis aMED, DASH, or Prudent dietary pattern scores had 15-24% lower MM-specific mortality per 1-SD increase, providing convergent evidence that healthier dietary habits are associated with longer MM survival.
| Effect size | HR 0.85 (aMED); HR 0.85 (DASH); HR 0.76 (Prudent) |
| CI | 95% CI 0.75 to 0.97 (aMED); 95% CI 0.76 to 0.95 (DASH); 95% CI 0.66 to 0.87 (Prudent) |
| Comparator | Lower aMED/DASH/Prudent scores (per 1-SD decrease, representing less healthy diet) |
| Effect summary | improvement; HR 0.85 (aMED); HR 0.85 (DASH); HR 0.76 (Prudent); CI: 95% CI 0.75 to 0.97 (aMED); 95% CI 0.76 to 0.95 (DASH); 95% CI 0.66 to 0.87 (Prudent) |
| Effect modifiers | [{"modifier": "Year of MM diagnosis (<2000 vs >=2000)", "interaction_p": "Pinteraction=0.04 for Prudent pattern; Pinteraction >0.05 for aMED, DASH", "direction": "null", "stratum_details": "Generally consistent associations in both strata. The Prudent pattern was the only exception with a borderline significant interaction (P=0.04), but associations remained in the same direction in both periods.", "plain_language": "The survival benefit of healthy eating patterns held regardless of whether modern myeloma therapies were available, though one diet score (Prudent) showed a slightly different magnitude of benefit across eras", "annotation_notes": "The Prudent pattern interaction (P=0.04) is borderline and was the only exception across all 8 dietary patterns. Authors note consistent benefits complementing even advanced therapies."}] |
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Outcomes
Source
PMC7423719
Pre-diagnosis dietary pattern and survival in patients with multiple myeloma