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Finding
Finding
decline
Multiple myeloma patients with higher pre-diagnosis Western dietary pattern scores had 24% higher MM-specific mortality per 1-SD increase in score, indicating that an unhealthy Western diet before diagnosis is associated with shorter survival.
| Effect size | HR 1.24 |
| CI | 95% CI 1.07 to 1.44 |
| Comparator | Lower Western pattern score (per 1-SD decrease, representing less Western-style diet) |
| Effect summary | decline; HR 1.24; CI: 95% CI 1.07 to 1.44 |
| Effect modifiers | [{"modifier": "BMI", "interaction_p": "Pinteraction=0.002 (MM-specific); Pinteraction=0.006 (all-cause)", "direction": "amplifies", "stratum_details": "Associations tended to be stronger for overweight and obese persons (BMI >=25) than those with lower BMI (<25). Only the Western pattern showed statistically significant heterogeneity by BMI.", "plain_language": "The harmful effect of a Western diet on myeloma survival was even worse for people who were overweight or obese", "annotation_notes": "This is the only dietary pattern with a statistically significant BMI interaction. Suggests overweight/obese MM patients may benefit most from dietary counseling to reduce Western-pattern foods."}, {"modifier": "Year of MM diagnosis (<2000 vs >=2000)", "interaction_p": "Pinteraction >0.05", "direction": "null", "stratum_details": "Generally consistent associations in both strata", "plain_language": "The harmful effect of a Western diet on myeloma survival held regardless of whether the patient was diagnosed before or after modern therapies", "annotation_notes": ""}, {"modifier": "Sex", "interaction_p": "Pinteraction >0.05", "direction": "null", "stratum_details": "No significant interaction between dietary patterns and sex", "plain_language": "The harmful association was similar for men and women", "annotation_notes": ""}] |
Connected entities
Interventions
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Outcomes
Source
PMC7423719
Pre-diagnosis dietary pattern and survival in patients with multiple myeloma