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Finding
Finding
improvement
Patients receiving ERT demonstrated statistically and clinically significant improvement in GAD severity compared to modified attention control, with large effect size on the time x group interaction, and 80% achieving high endstate functioning at 9-month follow-up.
| Effect size | Hedge's g = .83 |
| Follow-up | 9 months |
| Comparator | Modified attention control (MAC): four 15-minute therapist phone contacts at weeks 2, 5, 9, and 13 to assess clinical status and offer encouragement while awaiting open-label ERT |
| Effect summary | improvement; Hedge's g = .83 |
| Effect modifiers | [{"modifier": "Baseline GAD severity (CSR 4-5 vs 6-7)", "interaction_p": "p range .29 to .71", "direction": "null", "stratum_details": "Post-hoc subgroup analysis: patients with CSR 4-5 vs CSR 6-7 showed no differential GAD HEF response at any timepoint (X2's < 1.10)", "plain_language": "Patients with more severe anxiety at baseline responded just as well as those with less severe anxiety", "annotation_notes": "Post-hoc analysis requested during review."}, {"modifier": "Comorbid MDD diagnosis at baseline", "interaction_p": "p range .09 to .58", "direction": "null", "stratum_details": "Post-hoc subgroup analysis: patients with vs without comorbid MDD showed no differential GAD HEF response at any timepoint (X2's < 3.7)", "plain_language": "Having depression alongside anxiety did not reduce ERT's effectiveness for anxiety", "annotation_notes": "Important clinical finding \u2014 comorbid depression does not diminish GAD treatment response."}] |
Connected entities
Interventions
Conditions
Outcomes
Source
PMC5841545
A Randomized Controlled Trial of Emotion Regulation Therapy for Generalized Anxiety Disorder With and Without Co-Occurring Depression