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Finding
Finding
null
Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing significantly more adverse events (NNH 5 for oxycodone/acetaminophen, NNH 8 for cyclobenzaprine) including drowsiness, dizziness, and nausea.
| Effect size | No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen, NNH 8 for cyclobenzaprine |
| Follow-up | 1 week |
| Comparator | Naproxen plus placebo |
| Effect summary | null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen, NNH 8 for cyclobenzaprine |
| Adverse events | drowsiness, dizziness, nausea; NNH 5 for oxycodone/acetaminophen, NNH 8 for cyclobenzaprine |
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