Acute musculoskeletal disease

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen

Adding oxycodone/acetaminophen or cyclobenzaprine to naproxen for acute low back pain provided no benefit beyond naproxen alone for functional status, pain, or return to work at 1 week, while causing

Effect: null; No difference in functional status, pain, healthcare resource use, or return to work at 1 week; adverse events NNH 5 for oxycodone/acetaminophen