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Finding improvement
OnabotulinumtoxinA 200 U produced a greater 6-month mean reduction in daily urgency incontinence episodes than sacral neuromodulation (-3.9 vs -3.3 episodes per day; mean difference, 0.63; 95% CI, 0.13 to 1.14; P = .01), though the clinical importance of this small difference is uncertain.
Effect sizemean difference, 0.63 episodes per day
CI95% CI, 0.13 to 1.14
Follow-up6 months
ComparatorSacral neuromodulation (InterStim, first-stage lead placement with 7-14 day testing phase, permanent implant for responders)
Effect summaryimprovement; mean difference, 0.63 episodes per day; CI: 95% CI, 0.13 to 1.14

Connected entities

Interventions
OnabotulinumtoxinA 200 unit powder for solution for injection vial
Conditions
urgency urinary incontinence
Outcomes
urgency urinary incontinence episodes

Source

PMC5399419
OnabotulinumtoxinA vs Sacral Neuromodulation on Refractory Urgency Urinary Incontinence in Women A Randomized Clinical Trial
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